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We studied 14 chronic toluene abusers with a comprehensive neuropsychological evaluation and cerebral magnetic resonance imaging (MRI).These were 10 men and 4 women,and the mean age was 29 years.Using a blinded global assessment of neuropsychological functioning,we found 3 patients to be normal,3 in a borderline range,and 8 impaired.Independent analyses of white matter changes on MRI disclosed that the degree of white matter abnormality was strongly correlated(p<0.01)with neuropsychological impairment.Dementia in toluene abuse appears to be related to severity of cerebral white matter involvement. |
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